Very large and hairy, Baboon Spiders have heavy legs and large pedipalps. They are sedentary and ground-living, often found in burrows. Mainly nocturnal, they are found throughout southern Africa, generally in warmer, more arid areas. Some of the subspecies are venomous whilst others are harmless.

Normally slow-moving, they will rear up when provoked with forelegs in the air and the red markings under their chelicerae exposed. Due to their size they can inflict an extremely painful bite. In venomous subspecies, the neurotoxic venom is only mildly toxic to humans.